I doubt there is one single grand answer for the Fermi Paradox. Probably it's lots of smaller blockers which all stack up with each other. The chance of life forming, the chance that it becomes multicellular, the chance that it develops complex nervous systems, intelligence, the physiological hardware for tool use and creation, not stagnating or getting wiped out, having the inclination to look out and broadcast their existence, the chance that they survive long enough while doing this to exist at the same time as another civilization of comparable development, etc. It's easy to come up with these and even if they all have modestly small probabilities each, together they stack up to a plausible answer to the so called paradox.
The paradox would remain valid in my view. Even with all those stacked difficulties and plausibility levels, the galaxy alone is immense and if life of any kind were to be found, i'd argue that we should be able to see signs of sophisticated life somewhere at least, so where is it? It's still a cause for some speculation and maybe even existential worry.
The galaxy isn't really that huge. 10e11 stars. If you stack only a dozen obstacles at 10% odds of overcoming them each, you come up with advanced radio-broadcasting life being an unusual outcome for a galaxy our size. Add a few more and you can bet against another advanced civilization coinciding with us in the entire observable universe.