The paradox would remain valid in my view. Even with all those stacked difficulties and plausibility levels, the galaxy alone is immense and if life of any kind were to be found, i'd argue that we should be able to see signs of sophisticated life somewhere at least, so where is it? It's still a cause for some speculation and maybe even existential worry.
The galaxy isn't really that huge. 10e11 stars. If you stack only a dozen obstacles at 10% odds of overcoming them each, you come up with advanced radio-broadcasting life being an unusual outcome for a galaxy our size. Add a few more and you can bet against another advanced civilization coinciding with us in the entire observable universe.