I've been watching streams of 9 different models playing Factorio together [1] and it seems the answer is — not very well at all. They run into the same issue they have elsewhere in the game as well as in coding tasks: inability to create structured plans for the future.
So they get into a cycle of: 1. Get attacked 2. Build a few turrets 3. Get attacked. They don't consider buffing up their defenses or going out to deal with the threats or preemptively placing turrets when they expand. Not without human probing.
Also, they had the same issue with hand carrying resources around as some other comments here mentioned Sol did.