I believe this stems from an incomplete understanding of the problem space on my part (excuse the multiple puns); but, I am skeptical Knuth really said P=NP. There are so many mathemtical examples of equations that clearly show P≠NP. Computing in itself was originally formed from using iterative methods to solve hard problems. Least-squares methods, sin() cos(), traveling salesman, so many to list? To say P=NP for all problems seems like a fools errand to me.
See his answer to the seventeenth question in this interview:
https://www.informit.com/articles/article.aspx?p=2213858&WT....
> Don Knuth: As you say, I've come to believe that P = N P, namely that there does exist an integer M and an algorithm that will solve every n-bit problem belonging to the class N P in n**M elementary steps.
Do you understand what P and NP mean?