When you say responsive, you mean like it reacts quickly, or it responds to screen size?
In web we refer to the latter but i feel you mean the former.
I built a toy project in .NET 2005[0] with WinForms and the experience was actually excellent, binding data to controls was dead simple, it felt surprisingly modern. But i can't imagine how I'd make the UI resizable lol
Probably more responsive.
Windows apps always had to be able to respond to dynamically changing screen dimensions since the user could change from one screen resolution to another while an app was still running. Apps would get a WM_DISPLAYCHANGE message in their top-level windows message processing loop. Docs say WM_DISPLAYCHANGE was introduced in Win95.