No matter how many checks, there's a human trial, and that may not go to plan either: http://news.bbc.co.uk/1/hi/england/london/4811626.stm
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Two men who fell seriously ill following a clinical drugs trial remain in a critical condition but four others are showing signs of improvement.
All six are still in intensive care in Northwick Park Hospital, north-west London, after falling ill on Monday.
TeGenero, which manufactures the anti-inflammatory drug, says it has apologised to the men's families.
Okay, so let's not do the human trials. Just be content with the modelling (which is known to be imprecise especially where it matters most), and just approve the drug. What would that even solve? Instead of 6 volunteers getting injured, all the customers/patients who bought and took the drug would get harmed.
There is always human trial — the whole history/timeline of people taking a particular medicine is effectively a decades-long human trial. That's actually the only way we learn about long-term side effects, see paracetamol for instance. All you're proposing is we remove a smaller, controlled pre-trial before releasing the medicine into the wilder population. Sorry, but that won't solve anything except for your feeling of moral indignation.
All patients recovered, the final patient left hospital after 3 months. Not ideal. The company went bankrupt and the outcome was better regulation in the UK and Germany; great wiki article here: https://en.wikipedia.org/wiki/Theralizumab including the relevant: