It definitely can. By default it ships with the normal Tailscale DERP map but it also ships with a default-off DERP server. You can turn that on and set your DERP map to only include that one server (or you can fan out a couple if you want). At that point you're not using Tailscale assets at all.
Thanks! Once I have some more time this winter I will take a look at using this to replace my wireguard setup.