Another difference I remembered, this time a Microsoft-only idiocy: core Windows and Microsoft (Office) apps TRANSLATE shortcuts! Ctrl+A (“All”) becomes Ctrl+T (“Tudo”) in Notepad if the computer is in Portuguese. Ctrl+S also stops saving and is replaced by Ctrl+G (“Guardar”).

I can see why Microsoft thought this was a good idea, but the problem is that ONLY Microsoft apps do this, so you have two sets of shortcuts to remember. I don’t know a single person who likes this.