Caps Lock remapped to control. By using a keyboard where I can remap keys at the firmware level whenever possible, and in the OS when not

Ctrl-C doing different things come from different os/software lineages

You're still using your pinky for the most common modifier, not a good alternative

But in a far more natural form.

Actually, in many cases the opposite. If you have a classical Corner control, it can be used with a part of your palm with less movement, and you finger doesn't contort

"far more natural" would be if you moved pinky up or down. Sideways movements are only natural for your thumb

I move my whole hand around a lot, both by rotating at the wrist and moving at the elbow level.