Well naturally, Basecamp is collaboration software that class of apps probably belongs on the web.

There are probably others that don't need HTML user interfaces. I wasn't suggesting to use VB but there has to be modern UI native/client app frameworks or libraries. The problem IT departments had (speaking from personal experience) was the variation of client machines, DLL "hell" (shared library version conflicts) and patching. If the app is delivered and run as a container on the client's machine, a lot of those issues go away.