Yes it has to advance a lot. In a DC all your supporting equipment has returns to scale and can be repaired if it breaks. If a GPU breaks, a sysadmin walks over to the offending rack and swaps the card. In space all that equipment serves just a few cards (this is more like orbital server racks) and it has to work in space (so instead of using an ~infinite heat sink like the Earth, you use radiators etc). We still don't exactly know what effect radiation in LEO would have on stock GPUs - IIRC the experiments to determine this started after Elon went all in on orbital DCs. If anything breaks, you have a flying brick.

This is why that calculator, even under extremely optimistic assumptions for orbital, and even if you assume launch is zero, still cannot make it competitive with terrestrial.