> Pyston was an honest attempt at doing that

I'm still kinda sad that Pyston didn't happen

> but it has been dead for years partially because it hit many of these walls

Maybe this is one of the reasons. But I've also heard that Dropbox (which was making Pyston [0]), that used to heavily rely on Python, just decided that gradual migration to Go [1] is a more feasible approach than creating a faster Python implementation.

[0] https://dropbox.tech/infrastructure/introducing-pyston-an-up...

[1] "About a year ago, we decided to migrate our performance-critical backends from Python to Go to leverage better concurrency support and faster execution speed." - https://dropbox.tech/infrastructure/open-sourcing-our-go-lib...