Depends on how you use your computer. If you're mostly a developer/analysis terminal jockey with some browsing-- Qubes is a tremendous upgrade even if you don't care at all about the security properties:

The normal qube model of template OS vms + ephemeral app overlays makes it a cinch to troubleshoot complex issues because you can scribble all over the VM (e.g. go ahead, monkey patch your system LIBC if you want!) and all those changes will be gone when you restart the VM. Once you do find a solution you like, you can apply it cleanly and intentionally to the template. If all you were doing was a one-off, then no need to go make it permanent. Not sure if the latest Fedora upgrade is going to break stuff you care about? Install and switch to it one appvm at a time. Something breaks, file a bug and switch that one back until its fixed.

I've had friends screwing around with AI agents get their systems really screwed up because running the agent in a VM was work and requires maintenance. .. in qubes its just the natural way to run it, a few clicks and you're good to go. And the maintenance overhead of running in a VM is mostly non-existent.

If you ever use VPNs for privacy or to access protected networks-- Qubes is a big upgrade: You can run multiple VPN network VMs and then pick on an AppQube by AppQube basis which network they use. Then you don't have to worry about malware from your reddit browsing VM (or your Erotic MLP fanfic) going out over your employer's network or your banking going out via some Norwegian anonmization proxy that might spy on your traffic or cause your bank to instantly block your account. You can accomplish this without qubes but in qubes its particularly easy (and easy to get right): Every VM that has network access has it provided by another VM. Configure the networking how you like in that service VM and then pick what uses it.

When I say 'developer' above I don't mean to suggest that Qubes is particularly hard to use-- as I know significantly less technical people who use it without issue. But its non-security/privacy advantages are most significant if you're doing experimentation with the computer's configuration.

However if you're doing stuff that is Video heavy-- particularly gaming, and to a lesser extent CAD, video editing, etc. Qubes really brutally hurts video performance. It can be somewhat offset by running on higher end hardware (and then getting performance of a few year older system). Even just watching youtube videos is obvious impacted.

Similarly, it dents battery life. This is addressable via additional batteries given that now laptops are usbc powered and 100wh external batteries are readily available. But this is something of a lifestyle question.

Even before the AI-apocalypse I considered qubes to be non-negotiable on laptops-- there are just far far far too many browser RCE vulnerabilities to consider anything less for any computer that isn't a total security write-off.

Previously if I followed a link to a sus site and had my browser crash (maybe even the day before a RCE-in-the-wild was announced). I'd have some rationally justified paranoia that my whole computer might be compromised. Now, I can close the app VM (or-- better-- toss the disposable, which I try to use for most browsing) and know that even if they exploited the browser they'd have to have a VM escape of some kind too to do me any lasting damage.

The highest security stuff still ought to be on isolated hardware, of course. But using a multipurpose computer without qubes is unsafe at any speed, worse than driving without a seatbelt.

I dumped it after realizing Xen does its damndest in preventing you from hiding VM attributes from Guest OSes.

Proxmox uses KVM, and is easy to configure a VM to make the guest think it's on bare metal.

In the proprietary software space, a LOT of things run badly or refuse to run, or license stupidity with a guest OS. So for me, spoofing bare metal is an essential part of running ilk like Windows and proprietary apps. And also, school remote testing garbage.