Does mathematics still have a practical impact without humans in the loop? I don't think there's one single answer to that question, but I think it's worth considering exactly what that impact may be.
Tech companies are as much the topic of this post as AI, I think that's the immediacy.
To a significant extent, the pursuit of mathematics research is a pursuit of human understanding of mathematics, without knowing where it might lead, or whether it might lead anywhere at all. I don't see how the motivation for that goes away on its own, but the institution supporting it is certainly threatened by the potential loss of grant money and graduate student applications.