don't some of the adblock extensions randomly modify the fingerprinting you can get from this?

Hopefully, but it's good to have it disabled as well so that your system isn't screwed by the next zero day and to help cover you in case the fingerprinters manage to find a technique to get identifying data from WebGPU that your ad-blocker hasn't accounted for. It's a constant arms race after all. Hopefully the ad-blocker is still feeding them randomized data even with it disabled, but otherwise other randomized data points should keep your fingerprint unique even if a lack of WebGPU support stays consistent.