It's just not true that "neurochemistry prefers" one state over the other. Neurochemistry rewards you based on how you've trained yourself.

We used to gain status by being good hunters and warriors, and now we're trying to get it through clever hacker news comments. Believe me, "human nature" is very flexible.

People are just uncomfortable with uncertainty when they're not used to it. I think most of us have trained ourselves out of a lot of intense emotions in favor of seeing the big picture. I could give a hundred examples of this.