The privacy and security deficiencies of CalyxOS have nothing to do with compromises for usability. GrapheneOS provides much better usability including through having far broader app compatibility.
CalyxOS drastically reduces privacy and security compared to the Android Open Source Project. It recently went a whole year without privacy and security patches. They're currently months behind on providing current Pixel driver and firmware updates. It has never been a privacy or security hardened OS but rather the direct opposite.
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An operating system going a year without providing privacy and security patches is much worse than many options on that basis alone. It's currently months behind on updates. It's hardly the only other option available.