Didn't even bother looking into it because there's obviously not enough data yet to say anything substantial about GLP-1s and Alzheimers. But your comment should probably be the top.

GLP-1s have been used for over 20 years. There likely is enough data to say something, even if it's not water tight.

They've been used for over 20 years but until they became a weight loss drug recently, almost all of the research was on diabetics which introduces two confounding factors: diabetes and the diets diabetics already have to follow to manage the disease. It's hard to draw any conclusions when the results are muddied by those two factors.

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I’m not an expert on this, but haven’t GLP-1’s been used for quite a while on more limited scopes? So maybe there’s a cohort of people that could approach statistical significance.

IIRC, mostly used to help with type 2 diabetes... But effects on that cohort may not generalize to the general population.

This particular study was done on people without diabetes, at least.

Cognitive Decline != Alzheimer's. There are other forms of cognitive decline in aging.