Haven’t tried it but apparently there is an unofficial port of the full version of uBlock Origin to work on manifest v3, the largest challenge being that, on manifest v3, the webRequestBlocking permission is only available to enterprise sideloaded extensions: https://github.com/r58Playz/uBlock-mv3
Great but as soon as Google decides to completely strip the `webRequest` API from the codebase, it's game over. Now that it's deprecated it's only a matter of time. This also means Brave, the last Chromium-based browser to support it, will also be unable to support it