Absolutely. Running NixOS is a wonderful experience for this reason. NixOS + LLMs make it a breeze to make changes to your system, install and configure new software, and debug issues. Having every aspect of your system defined in a git repo is the perfect fit for agent harnesses.
I'll admit, even with LLMs to help, the Nix language and NixOS did have a rather steep learning curve, because it's quite different from anything I'd experienced before. But after getting the hang of it, I can't imagine going back to a "normal" OS and I'm very happy I put in the time to get over the initial friction.
You can also push deployments to remote systems which is great for servers and headless devices like raspberry pis. I use colmena and deploy-rs on different projects because they have some nice features but you can also do it with bare nix.
I have a repo for kiosk appliances that can build an SD card image for a specific device in a fleet (so no on device configuration is required) but it can also push out updates or changes at runtime. NixOS isn't perfect for embedded devices yet but works well for cases like this in my experience.