Interesting project! A long term vision for MacOS applications is feasible given the success of WINE/Proton with Windows applications.
Are you familiar with the Darling project? https://github.com/darlinghq/darling There's an open PR for ARM64 support https://github.com/darlinghq/darling/pull/1753 Could you combine efforts or do your goals differ too much?
The GitHub account is peculiar, it seemingly didn't have activity for two years after creation.
In their "License" section on Github, they write "This project is not derived from Darling." - so they clearly are familiar with it.
Wine got a lot of support from games, even today productivity apps are often much less supported.