Simple. If they put your company on something like the entity list that Huawei is on, nobody is going to work with you, public or private.
The US government can even force non-US banks from other countries to report oversea US citizens' income to the IRS, what makes you think they don't have the power or enforcement method to stop US-based entities from working with you?
I am a small entity, expecting less than $250k in yearly revenue. Somehow I’d be honored to be on that list. I wouldn’t expect to end up there either.
And I could just accept crypto to circumvent any actual regulation, of course that would not be the wording or advice on my service, I’d just disable bank and credit card payments for the US and allow Crypto payments only. That’s how a lot of Chinese and Russian services already operate and have so for over a decade.
Crypto would be convenient as I can even pay my inference in crypto and exchange it to cash at little to no scrutiny while still allowing it to be taxed.
If you're only accepting crypto, you're effectively not serving the US market and the policy would be considered successful.
My main market is still US. Largely US founders with startups and companies.