> But very sad he has no (real) tips on dealing with hand fatigue

I also spent a good amount of time in academia (math & physics), wrote everything by hand (dozens of pages per day), and I, too, suffered from serious hand fatigue & RSI for years, even when using a fountain pen. My recommendations:

- Use as light and as thick a fountain pen as possible. Also, very thin & hard pen tips may be nice but in my experience they make it harder to write.

- Work on your posture (if you don't do that already). Work out your neck and your back in particular to compensate for sitting all day every day. A stiff neck (even if you don't feel that it is stiff) can seriously impact the nerves in your arms & hands and, thus, muscle tension & recovery.

> Use as light and as thick a fountain pen as possible. Also, very thin & hard pen tips may be nice but in my experience they make it harder to write.

I use Fine-Medium nibs (some fine nibs are too fine, and some medium nibs are too thick).

Amusingly, I've discovered recently that my handwriting is much worse with thick pens. I write better with pens slightly on the thin side (but not too thin). Of course, that doesn't mean it's better for my wrist!