Whats always annoying is by using nested 4-port hub chips inside a hub with more than 4 ports you get very easily to the max nested depth limit (5). I have a monitor kvm switch that is also an usb hub. It itself only has two ports. Two usb hubs (that are internally nested) are plugged into those ports that I have at the back of my desk where all the HID are plugged in, but I also have a usb hub on the front of my desk so I can easily hotplugmy joysticks, yubikeys and usb flash drives.

Apparently that use case is very complicated with USB even in modern times :(