It would represent a pretty sharp inversion from all the progress of mathematical physics until the present.

Up until the present it has been a nearly uniform march of revealed symmetries, collapsed privileged frames of reference, and other such (in the deepest sense) simplifications in our model of reality that has improved its fidelity to the measurable.

I hang qualifier about these developments being simplifying because the result isn't simple in the details: quantum chromodynamics is a daunting subject! But it's not just an enumeration of details and contradictions, the particle zoo that preceded the Eightfold Way looked like line noise, now in indexed notation the Lagrangian of the entire Standard Model fits on a page (or so I've been told I've never actually seen the page).

It's almost tautological that the frontier where it's still messy involves an unrevealed symmetry or a persistent privileged frame of reference, that's what frontier means, we don't see past it to the seam where it folds up.

Personally I suspect AI systems will be a great deal more inclined to discard the parochial axioms that have every point placed human ego above simplicity.

It doesn't resolve all of the open problems in physics if you amputate consciousness, free will, agency persistent identity, and an unambiguous arrow of time.

But it starts looking possible to make progress.