I have HIV and am under treatment using medication, I have found D3 and K2 helps alleviate some of the side effects of the medication; largely my mood. Which makes a lot of sense because my immunity system is in constant daily activity.

However, I need to get more sunlight; I just don't think supplementation is the same as being in the sun. When I was homeless I never had these mood issues, but that's complicated, living day-to-day & meal-by-meal puts you survival mode so nothing is really past the hour.

All anecdotal, duh.