I primarily use Safari, and only switch to Chrome if a site misbehaves; every time I do so, I'm aghast by the ads and popups I suddenly get everywhere - despite having uBlock installed. I refuse to take that as an acceptable state of browsing the internet.
Safari has never supported MV2 uBlock Origin. Chrome with uBlock Lite is exactly the same as Safari with uBlock Lite.
In Safari, I use AdGuard and Consent-O-Matic, which catches pretty much everything.
Others in this thread disagree with you! But, if they're good enough for Safari, then you'll find they're exactly as good in Chrome.
https://chromewebstore.google.com/detail/adguard-adblocker/b...
https://chromewebstore.google.com/detail/consent-o-matic/mdj...