Would you be able to reseal the cracked glass and regenerate the vacuum through the other end?

More glass, epoxy, or similar?

Plastic generally isn't an air tight seal. The leaks may be slow, but generally we hope vacuum tubes last for years.

An accidental crack can be resealed, but if the crack had appeared because inappropriate materials were used, e.g. an unsuitable metal-glass pair, resealing is pointless, because cracks will appear again after the device is turned on and off several times, causing expansion-contraction cycles.