I'm no expert, but p53 is known as "the guardian of the genome."

If p53 is reactivated, the cancer cell dies.

https://en.wikipedia.org/wiki/P53

Perhaps a different mutation that disables p53 could evade the pattern match.

This article is all about p53.

Edit: This section of the wiki best explains this critical cellular component...

p53 regulates cell cycle progression, apoptosis, and genomic stability through multiple mechanisms:

-Activates DNA repair proteins in response to DNA damage, suggesting a potential role in aging.

-Arrests the cell cycle at the G1/S checkpoint upon DNA damage, allowing time for repair before progression.

-Initiates apoptosis if the damage is beyond repair.

-Essential for the senescence response triggered by short telomeres.