turn the stick around and grasp the other end.

evolution isnt about generating a response to a challenge, its about differential success.

those cells [oncocytes] that have properties conferring resistance carry it as un-utilized baggage, those without said properties make a living without that fetter.

the selective factor comes into play when payloaded LNP [in this case] facillitates destruction of "nonresistant" oncocytes and spare the "resistant"

the resistance is not generated in response to the challenge, it is already present, and confers survivorship in the face of the administration of the drug.