two scenarios i could think of where there's additional risk for bio/nuclear weapons 1) basement lab leaks and 2) improving quality of execution for shops that are already resourced enough to hire experts but maybe they're not that great.
i think the correct answer is probably to funnel more money to global (bio)security initiatives and maybe use ai leverage as a way to get more of the world on board. (some kind of access to nvidia or cloud ai or whatever in exchange for policy commitments deal- while that leverage lasts).
I just find doubtful that a LLM is going to help, instead of hurt, any state actor that is capable of starting a nuclear weapons problem.