I have a habit of reading obituaries and of getting a small reprieve when the cause of death is not cancer. I have the feeling that, for something that kills one in four people, we should be doing more as a society, and not leave the problem to a small group of people desperately fighting in the shadows. Thank you for your service, Dr. Scoyler.
It's an old person's disease. 30% of all cancers occur after the age of 74, 50% after 50.
I used to work in the pharmaceutical industry and my experience is that people in this field in particular are extremely passionate - you can immediately tell who lost loved ones to cancer.
One of the reasons cancer kills 1 in 4 people because we've eradicated lots of things that killed people before they were old enough to develop cancer. If we ever manage to cure cancer (or some cancers, because it's a taxonomy rather than a thing) then people will die of something else. No doubt we'll then wonder why we never spent enough effort curing whatever that is.
There will always be a reason why people die, and it will never feel like we're doing enough.
"because we've eradicated lots of things that killed people before they were old enough to develop cancer"
The other reason might be, we introduced lots of new cancer inducing compounds.
Also cancer is very complex and a broad term. "Solving" it likely requires solving the human body first, as in understanding every mechanism to the finest details.
Not to subtract from anything you said, but something that could help us, in the aggregate, as a society, is to frame things differently.
Today, most people say "human biology is a thing of wonder" "Humans are built for longevity". And when a terrible ailment strikes, they explain it with "The meaning of life/God/The devil/We must die of something!"
In my mind, we could create a human systems biology profession where students are told during the first day at school "human biology is a mess wrought up by mindless evolution. Your job is to bring it to the exacting standards of perfection that we are able to apply to other things. In the measure we succeed, we will be able to bring dignity to billions of people."
It’s not that we can’t fix things— given enough time and resources. It is just that we need to fix too many things. Each thing fixed only makes a small difference to average uptime, and that will be true for a long time, unfortunately.
We got some big early wins from low hanging fruit of infant mortality and poor sanitation. Everything else moves the needle a lot less, and it is a really long bug list. Our environment does ongoing damage of many different kinds and we wear out.
It's actually both - a thing of wonder wrought up by tens of millions of years of mindless evolution. And most scientists would already be happy to be able to "hack" this incredibly complex system to achieve a certain goal (e.g. cure cancer), not "refactor" the whole code, as you seem to be suggesting.
To add something, glioblastoma multiforme is really weird and our understanding of it is severely limited.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.20...
Lead paint/gasoline. Asbestos. Teflon. Chernobyl. Weedkiller. Just what I can think of since the 70s.
Yes. Modern life is a chemistry experiment. We are also exposed to various forms of radiation on a regular basis.
> If we ever manage to cure cancer ... then people will die of something else.
Well yes, people will still die, but in the process average life expectancy goes up. I think Aubrey de Grey once said that if you cured cancer and aging then the average life span would be seven hundred years or so, based on death rates due to accidents and murder, etc.
> There will always be a reason why people die, and it will never feel like we're doing enough.
That's the best of humanity: love for fellow human beings, and a desire to preserve life. And seeing that we live in an inconceivably vast and empty universe, I see nothing wrong with the idea.
Yes, and the other reason is we don’t invest enough.
Calling them all cancer is somewhat part of the problem I think.
It's not one disease, it is lots.