It's really difficult to reliably separate temporary and persistent browser storage. I tried at some point to reduce HDD noise. But given how neither Firefox or Chrome properly follow the XDG spec, it did not yield the results I wanted without a lot of handcrafted mounts.

In the end I'd guess you can also use some aspects of persistent storage to achieve similar results, even if the rest is actually tmpfs/RAM.

Indeed. Apps do always seem to keep adding new cruft to the filesystem layout. For a while my entire home directory was tmpfs on a few machines just to stop some of the tracking. I would commit my bookmarks back to persistent storage but that was it. It was a manual process and sometimes I would forget to commit but that's just my laziness. I'm sure others would automate this process.