That's a matter of taste, really. Good-quality brands with historically-good parts support are what I stick with.

If you like traditional coupes/sedans, Toyota or Lexus are probably good bets. I just read about a guy who is making a career out of restoring and reselling a specific Lexus model, which I thought was pretty cool: https://www.roadandtrack.com/news/a71435133/wisconsin-dealer... That kind of effort is going to become more common over the next few years, IMO.

If you like sports cars, Porsche peaked in the early-to-mid 2010s in terms of both quality and features.

If you like SUVs, I would think Japanese legacy brands would still be a good way to go. The last car on earth will probably be somebody's Toyota pickup or Land Cruiser from c. 2010.