Several air launch systems have been tried, with limited but non-zero commercial success. The altitude and speed you get from the plane is very small compared to the total work the rocket needs to do, so the benefit in terms of "the rocket can be smaller" is minimal. The main benefit in practice has been launching from ~wherever you like, since regular fixed launch sites usually have strict limits about the direction you have to fly to avoid people. But the economics of reusability are pushing rockets to get bigger, and no air launch system can fly anything nearly as big as a Falcon 9, much less a Starship + Super Heavy. Other scattered problems:

- Hanging under-wing is a totally different set of forces than standing vertically, especially for a big rocket with thin walls. You're more like a bridge than a tower, or rather like a bridge one moment and then a tower the next. You need reinforcement for that, which makes the vehicle heavier.

- Modern reusable rockets do quick "load and go" filling to keep their propellant as cold and dense as possible. You can't do that if you need to fuel on the ground and then hang off an airplane for ~an hour while it climbs.