OK, I get this. I gave email addresses to all my agent profiles using Migadu, which required a password from me somewhere -- with a whole team of agents, this is a lot of manual setup by default. After I gave them emails, I invited them to team plans and discovered the many services that detect them as bots despite their email address at a domain and mailserver with good reputation. There is a problem to be solved here.
That being said -- my agents only email each other and me! AgentMail is an OK start with the human <-> agent requirement, but consider that is a whitelist of a single email. The feature for AgentMail should be: we let your agent sign up easily for an email, and it has a very limited list of addresses and domains it can send outgoing email. This is very unlike normal email! I actually can't think of a single (human-facing) provider that will enable me to blacklist domains at the mailserver level to prevent outgoing mail from going to forbidden destinations.
Allowing a bot/agent to send email to any domain, with only a tagline to indicate the bot, is spam. But -- just like sandboxing the network and CLI commands available to the agent on my Mac Mini -- sandboxing an agent's email would just be the smart thing to do.
Pivot to an agent email sandbox and you will get plenty of the right kinds of customers, who won't ruin your mailserver reputation. Provide some easy agent-friendly whitelists out-of-the-box like same-custom-domain, and a similar approval system for new addresses/domains built on your OTP setup.