How do you do that if you only control one end?

Asymmetric encryption? Both you (the human) and the agent publish public keys, the agent sign/encrypt the OTP request with you public key, you verify/decrypt using your private key, then do the same the other way to send the OTP (always encrypted though, given you’re sending a secret).

Something like that?

But that doesn't help for the agent receiving mail from arbitrary 3rd parties

Oh sure I assumed they meant for the OTP

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