I used Tailwind in one web based product and it was alright, but I'll never go back to using it.

The HTML bloat was really tough to deal with. I spend far more time in HTML than I'd like, and having more Tailwind classes than I do semantic HTML was really tough to look at.

I've settled on using vanilla CSS and applying styles per-page on an as needed basis. For example, include base styles (reset, primary theme, etc) and then include marketing styles (or: blog styles, dashboard styles, syntax highlighting styles, charting styles, etc).

It keeps each page light and minimal. Reading the HTML is easy. Styles stay consistent across any pages that share styles, etc.