According to Sabine Hossefelder, there's no scientific basis to expect that a theory of everything exists (if I remember correctly this blog post) [1]. But I also have to say that, while I do find interesting what she talks about and I agree with her about some problems in academia she often complains about, for this very reason some other physicists don't like her and say she's wrong. But my understanding is that she still gets the Physics and Math parts right, it is her complaints about academia that some academics strongly disagree with.

[1] https://backreaction.blogspot.com/2020/07/do-we-need-theory-...