Are there any supplements that can work for neurogenesis? I've heard Lions Mane extract can do this, but I'm not sure. Anybody know of anything?
Are there any supplements that can work for neurogenesis? I've heard Lions Mane extract can do this, but I'm not sure. Anybody know of anything?
If you don't sleep 8+ hours a day every single day, exercise regularly, live in a place with clean air, eat clean food, don't drink alcohol, etc. you're losing your time, no amount of supplement will make up for our modern way of life, you're going to optimise the 0.1% while missing the 99.9% that matters
That is true, but keep in mind that routine is very difficult to do for someone that makes their living running the rat race, with stress, no time, responsibilities, worry, untreated health problems, etc. If you have the money, job security, then you'll have peace of mind. That will then allow one to live that kind of optimized lifestyle.
This is why we cannot abide scabs.
I see your point :)
Self-respect is an act of charity.
There's (minimal) research on psilocybin doing just that. One of the tragedies of prohibition is that we just weren't able to study these psychedelic compounds easily for 50+ years.
Not to take away from your point about psilocybin but the mushroom brought up, lions mane, is not hallucinogenic.
For sure, and lions mane is one of the three things Paul Stamets has been talking about for years to take in combination with niacin and psilocybin (microdose) to support neurogenesis. Low doses of psilocybin have only very mild perceptual changes, much less than smoking weed or drinking alcohol (for me).
Have any sources? I’d love to read what you are thinking about.
I haven’t used psilocybin in a clinical setting but have gone through an alternative psychedelic-assisted therapy process. Very interesting results and many positives.
There's not a lot, unfortunately. This paper is a literature review and the claims are weak, but there's something there that should be investigated further: https://pmc.ncbi.nlm.nih.gov/articles/PMC12392120/
Paul Stamets has evangelized psilocybin + lions mane + niacin for years in a microdosing format, but again, the research is lacking largely due to prohibition.
Not necessarily neurogenesis, but evidence of neuroplasticity: https://news.ycombinator.com/item?id=48030098
Cardiovascular exercise and strength training. Both are thought to contribute to neurogenesis, even in healthy people
Noopept
https://en.wikipedia.org/wiki/Omberacetam
Supposedly NGF eye drops https://www.independent.co.uk/news/science/is-this-the-secre...
Alpha-GPC and Uridine Monophosphate appear to have some effect, though minor. Also not exactly neurogenesis, but adjacent stuff. Evidence is complicated, there seems to be a signal but it's a weak effect.
Of note, cautionary tale is too much neurogenesis is brain cancer...
No, brain cancer is brain cancer.
which is poorly differentiated cells undergoing unchecked neurogenesis...
That’s like saying a fire on an oil rig is the same as combustion in a car engine
It’s not as bad an analogy as you make it sound. It is more like “fire is what makes our factories run, and oil fuels fire. So let’s douse our factories in gasoline to speed things up.”
I've read online that "Bacopa Monnieri" is a particularly strong and researched herbal supplement for cognitive maintenance, enhancement and neuroprotection, with the potential of supporting neurogenesis.
I've not tried that stuff since money is hard to come by these days. There have been a few human studies.
You can find more info here:
https://pubmed.ncbi.nlm.nih.gov/?term=bacopa+monnieri+cognit...
and here:
https://www.nccih.nih.gov/health/bacopa-monnieri
https://www.swansonvitamins.com/p/swanson-superior-herbs-bac...
Nicotine is the only psychoactive substance proven to increase intellectual function. Rote neurogenisis does not - much in the same way height isn’t a proxy for IQ. Stimulants like Adderall, Caffiene, etc are Dunning-Kruger by proxy.
You mean placebo? Not sure that Dunning-Kruger is applicable here
Maybe a better term is “stimulant-induced metacognitive miscalibration”. An induced a state of overconfidence similar to Dunning-Kruger - even thought the underlying mechanism is different.
You perceive the idea as great not because you suddenly understand it better or know more. You think the idea is great because of the dopamine flooding your brain. And much like Dunning-Kruger, even thought you might think you did better, real world results don’t match your expectations.
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