Assuming your key space is anything like randomly distributed.

Thinking about it--yeah, if you can anticipate anything like a random distribution it's a few extra instructions to reduce the number of values looked up. In the old days that would have been very unlikely to be a good deal, but with so many algorithms dominated by the cache (I've seen more than one case where a clearly less efficient algorithm that reduced memory reads turned out better) I suspect there's a lot of such things that don't go the way we learned them in the stone age.