I've recently built a script that periodically (every 25 minutes) fetches the latest merged PRs to check for some potential rule violations. I'm not an admin and couldn't get the events API working, so I just resorted to polling.
On an average ~8 hour working day, there's at least one failed request. In fact, looking over the logs, I can't spot a single day that did not have a failed request.
Now, I can't guarantee that these are all caused by GitHub (as opposed to my connection), but it is pretty funny.