Well I'd argue it'd help you to make designs that don't require perfect pixel alignments to look good, the same way developers should run crappy 10 year old computers. But that's the sadistic way. Anything graphics-related does require 1:1 display.

However, to be fair, that's only at lower DPIs smudging's an issue. Anything retina-ish and integer scaling loses all meaning. I'm typing this on a 15" 4K laptop on 1.75 scaling with HN set to 120% zoom. At those DPIs, it does not matter at all. I adjust most websites zoom level because a lot of them think the content must breathe, while I think I should not fiddle with my scroll to read a paragraph.