I've known people who've overdosed on Tylenol and died. I'm not saying that ibuprofen won't give you acid reflux and won't damage your kidneys, but due to <reason> I tend to take a lot of ibuprofen and also for <reason> take another medication that constricts my arteries and for <reason> get a lot of blood/urine work done... and my kidney function is good and despite everything I'm generally healthy. So I would say, like many things, what medicines you take probably depend on your specific body and situation. Regardless, you won't die accidentally from an acute ibuprofen overdose. You just might die from taking tylenol if you don't realize your liver is already damaged for other reasons. So there you go!

My mom fell (88 yo) X-rayed, nothing broken but ignored her history of ulcerative colitis (tough to do, given the colostomy bag she’s worn for 50 years). Sent her home with Motrin. Ended up in the hospital for two weeks with bleeding ulcers.

How the hell did the attending physician not see a colostomy bag during the exam?!

Unless you’re in Rhabdo. If you’re in so much muscle pain and your kidneys are working overtime to clear broken down tissue and you then hit them with too much ibuprofen, then you can go into kidney failure and die accidentally.

At least with the folks i hang around, liver damage from years of over-drinking is probably more likely

> You just might die from taking tylenol if you don't realize your liver is already damaged for other reasons.

If you don’t realize your kidneys are already damaged you might die from kidney failure because of ibuprofen.

Just don't take it on an empty stomach.

That's ibuprofen. Which can be partially mitigated by famotidine.

IBU: -stomach -kidneys -bp+ -clotting --NERD --NECD --NEUD --SNIUAA --SNIDR --DRESS

APAP: -liver --DRESS

-- extreme, rare side-effects

You expect us to know those acronyms?

I thought they were cheat codes.

--DRESS means your clothes with fall off.