From the article:

Only 40,960 words of memory. That’s only 90kb total memory to split between our code and the memory it needs at runtime.

Looking at a copy of Doom on the Internet Archive (https://ia800404.us.archive.org/view_archive.php?archive=/15...), DOOM.EXE is about 709k, and DOOM.WAD is about 11159k.

I think that's a pretty solid no.

Also it's a 250khz CPU. Not megahertz. Kilohertz. It's slower than the 1MHZ 8-bit home computers like the Apple ][ or c64.

"Running" Doom might be possible with some insane hack that offloads storage and/or processing to more modern hardware crammed into the UNIVAC case but given that this is one of two UNIVACs in the entire world, and the only one that actually runs, I don't think the museum is gonna let anyone cram a Raspberry Pi up in there.