As an American with severe hemophilia, 2020, without a doubt.

I was born in 1978, and in the early '80s, beat approximately 50/50 odds by not getting infected with HIV from the only available treatments at the time, and as a result of this and other risks including hepatitis, treatments were only used in response to active bleeding episodes throughout my childhood, resulting in arthritis in my ankles and elbows by the time I was around 8.

And I still wound up with hepatitis C from near birth (at which point it was referred to as "non-A, non-B", as the virus would not be identified until the late '80s) until a cure was developed decades later, fortunately never symptomatic.

So, while I beat the odds, my life expectancy from birth until much later would have been considerably longer had I been born in 2020, and my joints would work a lot better.

Oh, and as someone who grew up with the Shuttle and attended both Space Camp and Space Academy in Huntsville, inevitable political nonsense notwithstanding, I'm elated about the successful mission.

As for the odds, given the opportunity, I wouldn't even hesitate unless they were worse than 1 in 10.