The technique Anthropic uses was demonstrated by Nicholas Carlini in a talk he gave 2 weeks ago and it's very simple, when asking LLMs to review code, ask them to focus its review on one file in a single session. Here is the video with the timestamp (watch through to ~5:30, they show two different ways of prompting claude).
https://youtu.be/1sd26pWhfmg?t=204
https://youtu.be/1sd26pWhfmg?t=273
IMO the big "innovation" being shown by Mythos is the effectiveness with prompting LLMs to look for security vulnerabilities by focusing on specific files one at a time and automating this prompting with a simple script.
Prompting Mythos to focus on a single file per session is why I suspect it cost Anthropic $20k to find some of the bugs in these codebases. I know this same technique is effective with Opus 4.6 and GPT 5.4 because I've been using it on my own code. If you just ask the agent to review your pr with a low effort prompt they are not exhaustive, they will not actually read each changed file and look at how it interacts with the system as a whole. If the entire session is to review the changes for a single file, the llm will do much more work reviewing it.
Edit: I changed my phrasing, it's not about restricting its entire context to one file but focusing it on one file but still allowing it to look at how other files interact with it.
How is that going to find anything that interacts across files?
I would think that it is still capable of exploring the codebase and reading other related files like any other coding agent already does.
My phrasing wasn't clear but you aren't telling it to only look at one specific file but to focus its review on one file. Updated my original comment.