A spinal injury three years ago made me above-averagely aware of ergonomics, as I created a dedicated office (chairs, floating supports for monitors, keyboards, etc.) that would support the injury.
I have to say that I now access the 8 or so machines across my LAN and VPS via a Macbook Air rested on my lap, either through RDP or SSH. I probably use this 80% of the time. Because the machine is on my lap, held up at about 30 degrees on my lap, I can't say I ever noticed the sharp edges, until this post!