My issue with SimpleX is that the company is in the UK, and it's developed in the UK under UK law. https://simplex.chat/transparency/
Considering how fiercely anti-encryption the UK is/has become (because "only child molesters care about encryption!"), this is sadly reason enough for me not to trust it.
Do I believe they have a backdoor in their software? No.
But if the UK passes a law demanding they introduce one...