I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb
Bench 1rm: 315
Squat: 5x10 225
Deadlift: 5x5 315
After: same height lol, 154lb
Bench 1rm: 285
Squat: 5x10 205
Deadlift: 5x5 275
Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10 weeks, so I suspect thats why I lost muscle mass :/
This is crazy. You lost 28 lbs (15% of your body weight) in 10 weeks. Why did your doctor to allow you to continue? By any common sense, that is an unhealthy pace to lose body weight.
I used a combo of low-dose retatrutide, tesamorelin, and ipamorelin and lost about 15lb over 45 days, including 60% of my visceral fat, and put on 4lb of muscle, per before-and-after DEXA scans. I lifted regularly, ate well, and prioritized protein, and while I definitely under-ate protein, I was very pleased to find that I was able to increase muscle mass while cutting the fat. My visceral fat was the primary target here, since I'd been unable to get it to budge despite consistent training and diet. Very pleased.
You lost muscle because you lost around 1.54% of body weight per week, which is way too aggressive. The maximum recommended amount for losing weight while retaining muscle is around 1%. You will also most likely experience a weight rebound.
Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.
Not as far as I know. The ratio of fat-to-muscle loss depends on several factors, most notably the rate of weight loss (see https://pubmed.ncbi.nlm.nih.gov/34371981/). In fact, retatrutide is popular notably because it is known to preserve lean body mass better than other weight loss drugs.
It's interesting you mention this (anhedonia), since the guardian just published this article: https://www.theguardian.com/science/2026/apr/06/is-retatruti...
How did you actually feel? Disinterested in stuff, ennui, or other?
Even if you hadn't lost any muscle mass, zero chance you're going to see the same exercise performance on a calorie deficit.
Those are sizable drops for 10 weeks unless you stopped lifting as well
Mentioned above, but "I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)"
Did you work out during those 10 weeks any? TBH if you went from regular lifting to not for 10 weeks I'd expect a similar decrease in your lifting numbers (though not a .4lb/day weight loss of course)
I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)
Dude, you must be jacked. Great lifts at those weights. Unreal bench haha. Good shit, dude.
solid bench brother
thank you:^)